Manifestations of Histoplasmosis
Disseminated histoplasmosis can follow an acute or chronic course. An acute course frequently involves severely immunodepressed patients.
Acute presentations could be as follows-shock, respiratory distress, hepatic, coagulopathy, renal failure, obtundation.
Chronic presentation-The most common presentation is hepatosplenomegaly, elevated liver enzymes, oropharyngeal and gastrointestinal lesions. The skin, CNS, adrenals can be involved also

Manifestations of Coccidoides
Severely immunocompromised
Dyspnea, fever, night sweats, diffuse pulmonary process as in Pneumocystis Carinii

Less immunocompromised
Fever, cough, focal pneumonia

Disseminated coccidoides
Meningitis, skin and lymph node involvement

Manifestations of Blastomycoses
The characteristic rash in blastomycoses-verrucous lesions.


The first are the more characteristic verrucous lesions that usually appear on exposed body areas. These often begin as small papulopustular lesions and slowly spread to form crusted, heaped-up lesions that can vary in color from gray to a violaceous hue.